Product Information
About Neocate® SYNEO™ INFANT (with 2’-FL)
Neocate® SYNEO™ INFANT (with 2’-FL) is an amino acid-based Infant Formula for Special Dietary Use, with short-chain fructo-oligosaccharides and long-chain fructo-oligosaccharides (scFOS/lcFOS) and the probiotic Bifidobacterium breve M-16V for the dietary management of cow’s milk allergy (CMA), multiple food allergy (MFA) and other conditions where an amino acid-based formula is indicated.
The addition of 2’-FL to Neocate® SYNEO ™ has no effect on how the product should be used and tolerated. 4-7 Neocate® SYNEO ™ INFANT (with 2’-FL) is suitable for exactly the same patient population and can be prepared in exactly the same way as the current Neocate® SYNEO ™ formulation.
This updated formulation will have the same PBS code (11331J) and PHARMAC code (684713) as the current Neocate® SYNEO ™.
The ingredient list on Neocate SYNEO now includes, 2’-fucosyllactose (lactose), with lactose represented as a bolded allergen. This is to comply with Australian and New Zealand labelling regulations, which requires milk and all milk derivatives, which includes lactose, to be declared as an allergen on the food label.
The addition of 2’-fucosyllactose to Neocate SYNEO introduces a very low level of highly purified lactose to the formula (0.075mg/100kcal). For the majority of infants with cow’s milk allergy, small amounts of lactose in an amino acid formula do not typically cause adverse reactions.8
If you have any specific concerns or questions, we encourage you to discuss this further with your doctor.
You should be able to transition/swap straight from your current Neocate® SYNEO™ to the updated Neocate® SYNEO™ INFANT (with 2’-FL) recipe without any issues. If, in the unlikely event, you encounter a reaction, please contact your GP or healthcare provider.
The current Neocate® SYNEO ™ will be discontinued on October 1st to be replaced by the new formula with 2’-FL.
For any additional concerns or urgent queries, please contact your Nutricia Representative or the Nutricia Careline team on any of the following:
Phone:
AU: 1800 438 500
NZ: 0800 438 500
Email: nutriciacareline@danone.com
Features
- Hypoallergenic.
- Nutritionally complete, suitable as a sole source of nutrition for infants under 1 year.
- Contains long chain polyunsaturated fatty acids (LCPs) (docosahexaenoic acid (DHA) & arachidonic acid (ARA)).
- Contains the prebiotics, short and long chain FOSπ.
- Contains probiotic Bifidobacterium breve M16 V.
- Milk and soy protein free.
- π – Fructo-oligosaccharide.
- Contains Human identical Milk Oligosaccharide 2’-fucosyllactose (2’-FL)
Important Notice
- For enteral use only. Not for parenteral use.
- Must be used under medical supervision, after full consideration of all the feeding options, including breastfeeding.
- Suitable as a sole source of nutrition for infants under 1 year of age. Infants over 6 months should be offered foods in addition to formula.
- Neocate® SYNEO™ Infant (with 2′-FL) contains Bifidobacterium breve M-16V and is not suitable for use in premature infants or infants who are immunocompromised.
- Not recommended for infants with a central venous catheter, post-pyloric feeding tube or short bowel syndrome without full consideration of the risks and benefits by a healthcare professional and careful monitoring.
Contraindications for use
- Age restrictions
Neocate® SYNEO™ Infant (with 2′-FL) is suitable as a sole source of nutrition from birth until 12 months. For children above 12 months with specific clinical conditions and when recommended by a health care professional,Neocate® SYNEO™ Infant (with 2′-FL) may be used to supplement a CM elimination diet.
- Precautions and contraindications
Use Neocate® SYNEO™ Infant (with 2′-FL) only under medical supervision. Neocate® SYNEO™ Infant (with 2′-FL) contains Bifidobacterium breve M-16V and is not suitable for premature or immunocompromised infants. It is not suitable for parental use and is not recommended for infants with a central venous catheter, post-pyloric feeding tube or short bowel syndrome without full consideration of all risks and benefits by a healthcare professional and the patient is monitored.
Direction of Use
Powdered formula is not sterile.
The food should be prepared per serving and immediately prior to feeding. Formula must not be rewarmed during feeding and unfinished feeds should be discarded. Do not boil formula and do not use a microwave oven to prepare or warm formula. Warming and incorrect preparation can limit the benefits of Bifidobacterium breve M-16V. Always use the scoop provided.
- Suggested intake: The quantity of feed and the dilution should be determined by a clinician or dietitian only, and is dependent on age, bodyweight and medical condition of the patient.
- One level scoop (as provided in the tin) provides approximately 4.8 g of powder. Add one level scoop of powder to 30 ml of water to yield the recommended feed concentration of 14.4 %w/v (14.4 g per 100 ml).
- Follow the preparation instructions on the label of Neocate® SYNEO™ Infant (with 2’-FL).
Storage
- Store in a cool, dry place.
- Use by the date on bottom of the tin.
- Once opened, reseal packaging, store in a cool dry place (<25 °C, not a refrigerator) and use within one month.
- Some settling of the powder may occur.
Feeding Guide
| Approx. age of baby | Approx. weight of baby (kg) | Level scoops of Neocate Syneo | Cooled boiled water (ml) | Feeds in 24 hours |
|---|---|---|---|---|
| Birth | 3.5 | 3 | 90 | 6-7 |
| 2 weeks | 4 | 4 | 120 | 6 |
| 2 months | 5,5 | 5 | 150 | 5-6 |
| 3 months | 6 | 6 | 180 | 5 |
| 5 months | 7.5 | 7 | 210 | 4-5 |
| 7 months | 8.5 | 7 | 210 | 4 |
| 10 months | 9 | 8 | 240 | 4 |
Nutritional Information
| Average contents | Per 100g | Per 100mL* |
|---|---|---|
| NUTRITION INFORMATION | ||
| Energy | 1985 kJ | 286 kJ |
| 474 kcal | 68 kcal | |
| Fat (45En%) of which | 23.6 g | 3.4 g |
| — Saturated | 10.5 g | 1.5 g |
| — Monounsaturated | 9.3 g | 1.3 g |
| — Polyunsaturated | 3.8 g | 0.55 g |
| — Linoleic acid (LA) | 3.09 g | 445 mg |
| — α-Linoleic acid (LA) | 0.31 g | 45.0 mg |
| — Arachidonic acid (AA) | 0.12 g | 17.1 mg |
| — Docosahexaenoic (DHA) | 0.12 g | 17.1 mg |
| Carbohydrates (45En%) of which | 50.2 g | 7.2 g |
| — Sugars | 4.7 g | 0.67 g |
| Fibre (2En%) | 4.6 g | 0.66 g |
| — scFOS/lcFOS | 4.45 g | 0.64 g |
| — 2'Fucosyllactose (2'FL) | 0.14 g | 0.02 g |
| Protein equivalent (11En%) | 13.2 g | 1.9 g |
| Salt | 0.52 g | 0.08 g |
| Vitamins | ||
| Vitamin A | 415 μg | 59.7 μg |
| Vitamin D | 11.4 μg | 1.64 μg |
| Vitamin E | (9.48 α-TE/ET) 10.6 mg | (1.37 α-TE/ET) 1.52 mg |
| Vitamin C | 5.07 mg | 7.31 mg |
| Vitamin K | 42.8 μg | 6.17 μg |
| Thiamin (B~1~) | 0.57 mg | 0.08 mg |
| Riboflavin (B~2~) | 0.57 mg | 0.08 mg |
| Niacin (B~3~) | (9.25mg NE/EN) 3.94 mg | (1.33mg NE/EN) 0,57 mg |
| Vitamin B~6~ | 0.46 mg | 0.07 mg |
| Folic acid | 66.0 μg | 9.51 μg |
| Folate | 110 μg | 15.8 μg |
| Vitamin B~12~ | 1.33 μg | 0.19 μg |
| Biotin | 18.5 μg | 2.66 μg |
| Pantothenic Acid (B~5~) | 2.94 mg | 0.42 mg |
| Minerals and trace elements | ||
| Na | 209 mg | 30.0 mg |
| K | 520 mg | 74.8 mg |
| CI | 378 mg | 54.4 mg |
| Ca | 550 mg | 79.2 mg |
| P | 358 mg | 51.5 mg |
| Mg | 50.0 mg | 7.20 mg |
| Fe | 7.11 mg | 1.02 mg |
| Cu | 0.40 mg | 0.058 mg |
| Zn | 5.19 mg | 0.75 mg |
| Mn | 0.047 mg | 0.007 mg |
| F | ≤42.7 μg | ≤6.14 μg |
| I | 99.6 μg | 14.3 μg |
| Mo | 10.9 μg | 1.57 μg |
| Se | 18.0 μg | 2.59 μg |
| Cr | 10.4 μg | 1.50 μg |
| Others | ||
| Choline | 132 mg | 19.0 mg |
| Inositol | 106 mg | 15.3 mg |
| Taurine | 30.8 mg | 4.44 mg |
| Nucleotides | 16.6 mg | 2.39 mg |
| Osmolality | 360 mOsmol/kgH₂O | |
| *At the recommended feed concentration (14.4% w/v). | ||
| **oligosaccharide fibres |
Ingredients
Dried glucose syrup, refined vegetable oils (medium chain triglycerides (coconut and/or palm oil), high oleic sunflower oil, rapeseed oil, sunflower oil), dietary fibres (oligofructose (sc-FOS), inulin (lc-FOS), 2′-fucosyllactose), L-arginine L-aspartate, L-Leucine, L-lysine acetate, L-glutamine, L-proline, L-valine, emulsifier (E472c), L-isoleucine, glycine, L-threonine, dipotassium hydrogen phosphate, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-alanine, calcium phosphate dibasic, tripotassium citrate, sodium chloride, calcium carbonate, L-cystine, choline bitartrate, calcium glycerophosphate, L-tryptophan, calcium citrate, magnesium chloride, L-methionine, oil from Crypthecodinium cohnii, calcium phosphate tribasic, oil from Mortierella alpina, magnesium L-aspartate, inositol, L-ascorbic acid, antioxidants (sunflower lecithin, ascorbyl palmitate), taurine, ferrous sulphate, Bifidobacterium breve M-16V, zinc sulphate, L-carnitine, DL-alpha tocopheryl acetate, uridine 5`-monophosphate sodium salt, cytidine 5′-monophosphate, nicotinamide, calcium D-pantothenate, inosine 5′-monophosphate sodium salt, adenosine 5′-monophosphate, guanosine 5′-monophosphate sodium salt, copper sulphate, thiamin mononitrate, riboflavin, pyridoxine hydrochloride, retinyl acetate, potassium iodide, manganese sulphate, pteroylmonoglutamic acid, phytomenadione, sodium selenite, chromium chloride, sodium molybdate, D-biotin, cholecalciferol, cyanocobalamin. Bifidobacterium breve M-16V 1×1010 CFU/100g
- Vandenplas, et al. 2022; Nutrients, 14(3), 530
- Ramirez-Farias C, et al. 2021; Nutrients, 13(1), 186.
- Reverri EJ, et al. 2018; Nutrients, 10(10), 1346.
- Kajzer J, et al. 2016; The FASEB Journal, 30: 671.4-671.4.
- Candy DCA, et al. Pediatr Res. 2018;83(3):677–86.
- Reverri EJ et al. Nutrients. 2018; 10(10):1346
- Fox AT, et al. Clin Transl Allergy. 2019;9(1):5.
- Burks AW, et al. Pediatr Allergy Immunol. 2015;26(4):316